Investigador del Instituto Tecnológico de Massachussets y de la Facultad de Medicina de Boston, Bioquímico y Doctor en Medicina, Barry Sears es un pionero en el campo de la biotecnología y trabajó durante años en la investigación y desarrollo de medicamentos contra el cáncer y las enfermedades coronarias. Sus trabajos le llevaron a descubrir la técnica del control de los eicosanoides, fundamento científico de sus dietas. Además de diversos trabajos médicos y científicos, ha publicado varios libros, entre los que destacan La revolucionaria dieta de la Zona, En la Zona con Omega 3 Rx, Rejuvenecer en la Zona y La inflamación silenciosa. Todos ellos han sido bestsellers internacionales, han ayudado a millones de personas a mejorar su salud y han sido traducidos a 22 lenguas en 40 países.


Barry Sears, Ph.D.

Curriculum Vitae

Fecha de nacimiento:             6 de junio de 1947
Lugar de nacimiento:             Long Beach, California
Áreas de investigación:        Modulación de la respuesta hormonal por la dieta, biosíntesis de eicosanoides y desarrollo de sistemas de liberación intravenosos y transdérmicos.

Formación:

1964-1968         A.B. (con honores) Occidental College
1968-1971         Doctor en Medicina. Indiana University

Formación postdoctoral:

1971-1974         University of Virginia Medical School, Departamento de Bioquímica
1974-1975         Boston University Medical School, Departamento de Medicina

Posiciones académicas:

1975-1978             Instructor de investigación, Departamento de Medicina, Boston University Medical School
1978-1982             Investigador, National Magnet Laboratory, Massachusetts Institute of Technology
2003-actualidad     Presidente, Inflammation Research Foundation, Marblehead, Massachusetts

Posiciones en la industria:

1976-1986            Presidente, Lipid Specialties, Inc.
1986-1992             Presidente, BIOSYN, Inc.
1992-actualidad     Presidente, Surfactant Technologies, Inc.
1996-1999             Presidente, Eicotech Corporation
1999-actualidad     Presidente, Zone Labs, Inc.

Publicaciones

1. Griffiths, R.R., Sears, B., and Jennings, L.B. "Specificity of transfer of a learned response by intracisternal injection of brain extract from trained rats: negative findings." Psychological Reports 25: 339-348 (1969)
2. Baumrucker, J., Calzadilla, M., Centeno, M., Lehrmann, G., Linquist, P., Dunham, D., Price, M., Sears, B., and Cordes, E.H. "Secondary valence force catalysis. XI. Enhanced reactivity and affinity of cyanide ions elicted by ionic surfactants." J Phys Chem 74: (1970)
3. Baumrucker, J., Calzadilla, M., Centeno, M, Lehrmann, G., Urdaneta, M., Linquist, P., Dunham, D., Price, M., Sears, B., and Cordes, E.H. "Secondary valence force catalysis. XII. Enhanced reactivity and affinity of cyanide toward N-substituted 3-carbomoyl-pyridinium ions elicted by ionic surfactants and biological lipids." J Am Chem Soc 94: (1972)
4. Williams, E., Sears, B., Allerhand, A., and Cordes, E.H. "Segmental motion of amphipathic molecules in aqueous solutions and micelles. Applications of natural abundance 13C partially relaxed fourier transform nuclear magnetic resonance spectroscopy. J Am Chem Soc 95: (1973)
5. Sears, B., Hutton, W.C., and Thompson, T.E. "13C NMR studies on bilayers formed from synthetic di-10-methyl-stearoyl phosphatidylcholine enriched with 13C in the N-methyl carbons." Biochem Biophys Res Comm 60: 1141-147 (1974)
6. Sears, B. "13C Nuclear Magnetic Resonance Studies of Egg Phosphatidylcholine." J Mem Biol 20: 59-73 (1975)
7. Sears, B., Hutton, W.C., and Thompson, T.E. "Effects of paramagnetic shift reagents on the 13C nuclear magnetic resonance spectra of egg phosphatidylcholine enriched with 13C in the N-methyl carbons." Biochemistry 15: (1976).
8. Yeagle, P.E., Hutton, W.C., Martin, R.B., Sears, B., and Huang. C. "Transmembrane asymmetry of vesicle lipids." J Biol Chem 251: (1976)
9. Sears, B., Deckelbaum, R.J., Janiak, M.J., Shipley, G.G., and Small, D.M. "Temperature dependent 13C nuclear magnetic resonance studies of human serum low density lipoproteins." Biochemistry 15: (1976)
10. Curatolo, W.C., Shipley, G.G., Small, D.M., Sears, B., and Neuringer, L.J. "Effect of lectin-induced agglutination on 13C nuclear magnetic resonance line width in sonicated phospholipid/glycolipid vesicles." J Amer Chem Soc 99: (1977)
11. Roseman, M.A., Lentz, B., Sears, B., Gibbes, D., and Thompson, T.E. "Properties of sonicated vesicles of three synthetic phospholipids." Chem Phys Lipids 21: 205-210 (1978)
12. Curatolo, W.C., Yau, A.O., Small, D.M., and Sears, B. "Lectin-induced agglutination of phospholipid/glycolipid vesicles." Biochemistry 17: (1978)
13. Neuringer, L.J., Sears, B., and Jungalwala. "Difference in orientational order in phospholipid and sphingomyelin bilayers. FEBS Letters 104: 173-175 (1979)
14. Neuringer, L.J., Sears, B., and Jungalwala, F.B. "2H NMR studies of the interaction of cerebrosides with dipalmitoyl phosphatidylcholine in bilayers." Biochim Biophys Acta 558: 325-329 (1979)
15. Widder, K.J., Senyei, A.E. and Sears, B. "Experimental methods in cancer therapeutics." J Pharm Sci 71: 379-387 (1982)
16. Mendelsohn, R., Dluhy, R.A., Curatolo, and Sears, B. "Order and fluidity in terminal methyl regions of dipalmitoyl phosphatidylcholine mutilayers: a comparison of Raman and deuterium NMR spectroscopy." Chem Phys Lipids 30: 287-291 (1983)
17. Stark, R.E., Manstein, J.L., Curatolo, W.C., and Sears, B. "Deuterium NMR of bile salt/phosphatidylcholine mixed micelles." Biochemistry 22: (1983)
18. Curatolo, W.C., Sears, B., and Neuringer, L.J. "A calorimetry and deuterium NMR study of mixed model membranes of 1-palmitoyl-2-oleyl phosphatidylcholine and saturated phosphatidylcholines." Biochim Biophys Acta 817: 261-270 (1985)
19. Curatolo, W.C., Jungalwala, F.B., Sears, B., Tuck, L., and Neuringer, L.J. "Deuterium NMR spectroscopy of biosynthetically deuterated mammalian tissues." Biochemistry 24: (1985)
20. Sears, B. "Essential fatty acids and dietary endocrinology: a hypothesis for cardiovascular treatment." J Adv Med 6: 211-224 (1993)
21. Sears, B. "The Zone diet and athletic performance." Sports Med 99: 289-291 (2000)
22. Bell, S.J. and Sears, B. "Low-glycemic load diets: Impact on obesity and chronic diseases." Crit Rev Food Sci and Nutr 43(4):357-377 (2003)
23. Bell, S.J. and Sears, B. "A Proposal for a New National Diet: A Low-Glycemic Load Diet with a Unique Macronutrient Composition." Metabol Synd and Related Disord 1:199-208 (2003).
24. Bell, S.J. and Sears, B. "The Zone Diet: An Anti-Inflammatory, Low Glycemic-Load Diet." Metabol Synd and Related Disord 2:24-38 (2004).
25. Johnston, C.S., Tjonn, S.L,, Swan, P.D., White A., Hutchins H., and Sears B. "Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets." Am J Clin Nutr 83: (2006)

1. Sears, B. The Zone. Regan Books (Harper Collins). New York, NY. (1995)
2. Sears, B. Mastering the Zone. Regan Books (Harper Collins). New York, NY (1997)
3. Sears, B. Zone Perfect Meals in Minutes. Regan Books (Harper Collins). New York, NY (1997)
4. Sears, B. Zone Food Blocks. Regan Books (Harper Collins). New York, NY (1998)
5. Sears, B. The Anti-Aging Zone. Regan Books (Harper Collins). New York, NY (1999)
6. Sears, B. A Week in the Zone. Regan Books (Harper Collins). New York, NY (2000)
7. Sears, B. The Soy Zone. Regan Books (Harper Collins). New York, NY (2000)
8. Sears, B. 100 Great Zone Foods. Regan Books (Harper Collins). New York, NY (2001)
9. Sears B. The Omega Rx Zone. Regan Books (Harper Collins). New York, NY (2002)
10. Sears, B. and Sears, L. Zone Meals in Seconds. Regan Books (Harper Collins). New York, NY (2004)
11. Sears, B. The Anti-Inflammation Zone. Regan Books (Harper Collins). New York, NY (2005)

1. Sears, B. "Phosphatidyl quarternary ammonium compounds." U.S. Patent No. 4,086,257 (1978)
2. Sears, B. "Phosphatidyl sulfonium compounds." U.S. Patent No. 4,097,502 (1978)
3. Sears, B. "Phosphatidyl phosphonium compounds." U.S. Patent No. 4,097,503 (1978)
4. Sears, B. "Method for determining the level of LDL cholesterol in blood plasma." U.S. Patent No. 4,126,416 (1978)
5. Sears, B. "Method of preparing a controlled release pharmaceutical preparation." U.S. Patent No. 4,145,410 (1979)
6. Sears, B. "Kit for determining the level of LDL cholesterol in body fluids." U.S. Patent No. 4,190,628 (1980)
7. Sears, B. and Yesair, D.W. "Xenobiotic delivery vehicles." U.S. Patent No. 4,298,594 (1981)
8. Sears, B. "Method of emulsifying cholesterol, cholesterol esters, and triglyceride compounds." U.S. Patent No. 4,320,121 (1982)
9. Sears, B. "Synthetic phospholipid compounds." U.S. Patent No. 4,426,330 (1984)
10. Sears, B. "Magnetic compositions and magnetic memory devices prepared." U.S. Patent No. 4,507,217 (1985)
11. Sears, B. "Synthetic phospholipid compounds." U.S. Patent No. 4,534,899 (1985)
12. Sears, B. "Method for reducing blood pressure levels in hypertensive persons." U.S. Patent No. 5,059,622 (1991)
13. Sears, B. "Method of and nutritional and pharmaceutical compositions for reduction of hyperinsulinemia." U.S. Patent No. 6,140,304 (2000)